POSITIONING WHOLE EXOME SEQUENCING IN THE DIAGNOSTIC PATHWAY FOR RARE DISEASE TO OPTIMISE UTILITY: A PROTOCOL FOR AN OBSERVATIONAL COHORT STUDY AND AN ECONOMIC EVALUATION

Introduction Despite the superior diagnostic performance of exome and genome sequencing compared with conventional genetic tests, evidence gaps related to clinical utility and cost effectiveness have limited their availability in routine clinical read more practice in many jurisdictions.To inform adoption and reimbursement policy, this protocol pro

We study the relationship between the sentiment levels of Twitter users and the evolving network structure that the users created by @-mentioning each other.We use a large dataset of tweets to which we apply three sentiment scoring algorithms, including ilootpaperie the open source SentiStrength program.Specifically we make three contributions.Firs

Nowadays, there is a need for tools to support city planners in assessing the performance of cycling infrastructure and managing bicycles and mixed flows.Microscopic and macroscopic bicycle traffic models can be used to color touch 7/97 fulfill this need.However, fundamental knowledge on individual cyclist interaction behavior (which should underpi

IntroductionHIV transmission continues among gay and bisexual men who have sex with men (GBMSM), with those who are younger, or recent migrants, or of minority ethnicity or who are gender diverse remaining at increased risk.We aimed to identify and describe recent studies evaluating the effectiveness of HIV prevention interventions for GBMSM in hig